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Alzheimer Disease with Early Onset

MedGen UID:
155465
•Concept ID:
C0750901
•
Disease or Syndrome
Synonyms: Alzheimer Disease, Early Onset; Early Onset Alzheimer Disease; Presenile Alzheimer Dementia

Definition

Evidence of Alzheimer''s disease with early onset. [from NCI]

Professional guidelines

PubMed

Genotype-phenotype correlation in early-onset Alzheimer disease with presenilin 1 gene mutations.
Larner AJ
Arch Neurol 2004 May;61(5):801. doi: 10.1001/archneur.61.5.801-a. PMID: 15148163

Recent clinical studies

Etiology

Development and assessment of algorithms for predicting brain amyloid positivity in a population without dementia.
Le Scouarnec L, Bouteloup V, van der Veere PJ, van der Flier WM, Teunissen CE, Verberk IMW, Planche V, Chêne G, Dufouil C
Alzheimers Res Ther 2024 Oct 11;16(1):219. doi: 10.1186/s13195-024-01595-5. PMID: 39394180
Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform MRAD developed based on Mendelian randomization analysis.
Zhao T, Li H, Zhang M, Xu Y, Zhang M, Chen L
Elife 2024 Oct 11;13 doi: 10.7554/eLife.96224. PMID: 39392298Free PMC Article
Genetics-driven risk predictions leveraging the Mendelian randomization framework.
Sens D, Shilova L, Gräf L, Grebenshchikova M, Eskofier BM, Casale FP
Genome Res 2024 Oct 11;34(9):1276-1285. doi: 10.1101/gr.279252.124. PMID: 39332904

Diagnosis

Development and assessment of algorithms for predicting brain amyloid positivity in a population without dementia.
Le Scouarnec L, Bouteloup V, van der Veere PJ, van der Flier WM, Teunissen CE, Verberk IMW, Planche V, Chêne G, Dufouil C
Alzheimers Res Ther 2024 Oct 11;16(1):219. doi: 10.1186/s13195-024-01595-5. PMID: 39394180
Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform MRAD developed based on Mendelian randomization analysis.
Zhao T, Li H, Zhang M, Xu Y, Zhang M, Chen L
Elife 2024 Oct 11;13 doi: 10.7554/eLife.96224. PMID: 39392298Free PMC Article
Evolution of Detecting Early Onset of Alzheimer's Disease: From Neuroimaging to Optical Immunoassays.
Hsiao WW, Angela S, Le TN, Ku CC, Hu PS, Chiang WH
J Alzheimers Dis 2023;93(3):821-845. doi: 10.3233/JAD-221202. PMID: 37125550

Therapy

Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease.
Cummings J, Osse AML, Cammann D, Powell J, Chen J
BioDrugs 2024 Jan;38(1):5-22. Epub 2023 Nov 13 doi: 10.1007/s40259-023-00633-2. PMID: 37955845Free PMC Article
The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?
Megur A, Baltriukienė D, Bukelskienė V, Burokas A
Nutrients 2020 Dec 24;13(1) doi: 10.3390/nu13010037. PMID: 33374235Free PMC Article
Sequential drug treatment algorithm for agitation and aggression in Alzheimer's and mixed dementia.
Davies SJ, Burhan AM, Kim D, Gerretsen P, Graff-Guerrero A, Woo VL, Kumar S, Colman S, Pollock BG, Mulsant BH, Rajji TK
J Psychopharmacol 2018 May;32(5):509-523. Epub 2018 Jan 17 doi: 10.1177/0269881117744996. PMID: 29338602Free PMC Article
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM
Neuron 2007 Feb 1;53(3):337-51. doi: 10.1016/j.neuron.2007.01.010. PMID: 17270732
Alzheimer's disease.
Blennow K, de Leon MJ, Zetterberg H
Lancet 2006 Jul 29;368(9533):387-403. doi: 10.1016/S0140-6736(06)69113-7. PMID: 16876668

Prognosis

Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
J Sleep Res 2021 Aug;30(4):e13229. Epub 2020 Dec 2 doi: 10.1111/jsr.13229. PMID: 33289311Free PMC Article
Genetic Markers of Alzheimer's Disease.
Nikolac Perkovic M, Pivac N
Adv Exp Med Biol 2019;1192:27-52. doi: 10.1007/978-981-32-9721-0_3. PMID: 31705489
Early-onset Alzheimer Disease and Its Variants.
Mendez MF
Continuum (Minneap Minn) 2019 Feb;25(1):34-51. doi: 10.1212/CON.0000000000000687. PMID: 30707186Free PMC Article
Early-Onset Alzheimer Disease.
Mendez MF
Neurol Clin 2017 May;35(2):263-281. doi: 10.1016/j.ncl.2017.01.005. PMID: 28410659Free PMC Article
Early-onset familial Alzheimer's disease (EOFAD).
Wu L, Rosa-Neto P, Hsiung GY, Sadovnick AD, Masellis M, Black SE, Jia J, Gauthier S
Can J Neurol Sci 2012 Jul;39(4):436-45. doi: 10.1017/s0317167100013949. PMID: 22728850

Clinical prediction guides

Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease.
Valdes P, Henry KW, Fitzgerald MQ, Muralidharan K, Caldwell AB, Ramachandran S, Goldstein LSB, Mobley WC, Galasko DR, Subramaniam S
Mol Brain 2023 Nov 3;16(1):75. doi: 10.1186/s13041-023-01063-5. PMID: 37924159Free PMC Article
Epilepsy in Early Onset Alzheimer's Disease.
Haoudy S, Jonveaux T, Puisieux S, Epstein J, Hopes L, Maillard L, Aron O, Tyvaert L
J Alzheimers Dis 2022;85(2):615-626. doi: 10.3233/JAD-210681. PMID: 34864663
Exosomal biomarkers in Down syndrome and Alzheimer's disease.
Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC
Free Radic Biol Med 2018 Jan;114:110-121. Epub 2017 Sep 5 doi: 10.1016/j.freeradbiomed.2017.08.028. PMID: 28882786Free PMC Article
Early- and late-onset Alzheimer disease: Are they the same entity?
Tellechea P, Pujol N, Esteve-Belloch P, Echeveste B, García-Eulate MR, Arbizu J, Riverol M
Neurologia (Engl Ed) 2018 May;33(4):244-253. Epub 2015 Nov 3 doi: 10.1016/j.nrl.2015.08.002. PMID: 26546285
Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9.
Paquet D, Kwart D, Chen A, Sproul A, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S, Tessier-Lavigne M
Nature 2016 May 5;533(7601):125-9. Epub 2016 Apr 27 doi: 10.1038/nature17664. PMID: 27120160

Recent systematic reviews

Sleep in Alzheimer's disease: a systematic review and meta-analysis of polysomnographic findings.
Zhang Y, Ren R, Yang L, Zhang H, Shi Y, Okhravi HR, Vitiello MV, Sanford LD, Tang X
Transl Psychiatry 2022 Apr 1;12(1):136. doi: 10.1038/s41398-022-01897-y. PMID: 35365609Free PMC Article
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: a systematic review.
Jeremic D, Jiménez-Díaz L, Navarro-López JD
Ageing Res Rev 2021 Dec;72:101496. Epub 2021 Oct 21 doi: 10.1016/j.arr.2021.101496. PMID: 34687956
The Amyloid-β Pathway in Alzheimer's Disease.
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A
Mol Psychiatry 2021 Oct;26(10):5481-5503. Epub 2021 Aug 30 doi: 10.1038/s41380-021-01249-0. PMID: 34456336Free PMC Article
Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review.
Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E
J Sleep Res 2021 Aug;30(4):e13229. Epub 2020 Dec 2 doi: 10.1111/jsr.13229. PMID: 33289311Free PMC Article
Systematic Review of miRNA as Biomarkers in Alzheimer's Disease.
Swarbrick S, Wragg N, Ghosh S, Stolzing A
Mol Neurobiol 2019 Sep;56(9):6156-6167. Epub 2019 Feb 8 doi: 10.1007/s12035-019-1500-y. PMID: 30734227Free PMC Article

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